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ACTIVITY REPORT 2014

Establishment of Thalasemia Center on 01-01-2013

Establishment of Skill Development Center on 01-01-2012

Establishment of Youth Research Center 01-02-2012

A Free Medical Camp by HOPE Organization was held on 02/02/2012 at 10:00 hrs.

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Thalassemia Center
 
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Polio Eradication Project
 
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Press Reports 2014
 
 
 
 

Thalassemia

Cooley”s anemia

The thalessemia are a divorse group of genthic blood diseases.

Thalessemia is the most common inherited single gene disorder in the world.
Scientists & public officials predict that thalessemia will become a world issue in the next century. With global improvement in childhood diseases prevention and treatment , more focus will be given to diagnosing disorders. It is our hope that by providing education about the disease we can raise awareness, encourage people to get tested for the trait ( Hb, electrophorsis) and spread knowledge about comprehensive treatment the thalessemia are a divorse group of genetic blood, disease charaterized by absent or decreased production of normal hemoglobin, resulting in a microcytic anemia of varying degree. The thalessemia have a distribution concomitant with areas where malaria is common. People with thalessemia have a distribution concomitant with areas were maleria is common.

 
People with thalessemia minor are able to fight malaria better than who do not have it, therefore in parts of the world where malaria existed thalessemia minor increased. This was of great value in the past since malaria was rampant and deadly however malaria is in longer problem in many areas of the world. Thelessemia minor has no advantage to people in these areas. The alpha thalessemia are seen primarily in the mediterranean sea area, Africa and Southeast Asia. Due to global immigration in the patterns, these have been an increase in advice of thalessemia in North America in the last 10 years.
 

In thalessemia patient , a mutation or deletion of the genses, that control global production accurse, this leads to a decrease production of the correspondings globin chain and an abnormal hemoglobin ratio. This abnormal ratio leads to decrease synthesis of hemoglobin and expression of thalessemia .  the globin that is produced in normal amount winds up in excess and forms red cells aggregates or inclusion. These aggregate becomes oxidized and damaged the cell membranes leading to hemolytic, ineffective erythropoiesis or both, the quantity and properties of these globin chain aggregates determine the characteristics and severity of the thalessemia.

 

Thalessemia Minor

Your blood count may be a little lower than other people of your age and sex, but this produces no sympthoms. You were born with this condition and you will have it all of your life time, there is no need for treatment and most people who have inherited this are not sick and probaby do not know they have it. A mild form of thalessemia minor may be mistaken for iron deficiency anemia. Iron medicines are necessary not useally and will not help your anemia. They could even be harmful if taken over a long period of time if you marry a person who does not have want to take this risk in planning your family. Thalessemia minor does not changed into thalessemia.

 

Thalessemia Major

Thalessemia major occurs when a person inherits two thalessemia genes, one from each parent. Both parents must have thalessemia minor. When two individuals who have thalessemia minor marry, there is a 25% chance that any pregnancy can result in a child with thalessemia major, two of four children will have thalessemia minor and 1 of 04 will be normal. These chances are present with each pregnancy sone families have had only one ill child, while others have had all of their children affected.

 

Sympthoms of Thalessemia Major

An infant with thalessemia major appears normal at birth. If a child is well for the first five years of life a diagnosis of thalessemia major is unlikely. The double dose of two thalessemia genes causes an anemia that is so severe that regular blood transfusion may be given throughout life.

 

A new born with thalessemis major appears normal at birth. As they grow,infants with thalessemia major exhibits paleness and fussiness, weakness and slow growth appears in the first or second year of life the abdomen may swell due to an enlarge liver and spoleen, changes occurs in the appearance of the face and head. The eyes appear slanted and the cheek bones become prominent.

Treatment for thalessemia Major

Treatment involes blood transfusion that may be given every 04-06 weeks to sustain life. Comlications that may arise from regular blood transfusion include an over load of iron buidling in vital organs causing diabetes, liver disease and heart failure the spleen may become so enlarged or oceractive that it has to be removed surgically. in the past many patients died in their teens due to these cmplications.

 

today, a medicines called deferoxamine (desferol infusion) can remoccve iron from the body, but must be given by slow infusion under the skin or in a vein over 10-12 hours five to secen times a week using a battery drivine pimp with tansfusion and continuous of desferol, the life expectancy of patient with thalassemia mahor has been greatly improced and many patients reaching thir thirties and even beyond. Management of thalassemia is not enough, researcher are investigating two potentially crative and treatment: bone marrow translantation and ene therapy both method have shown promise.

 

Tasting of Thalassemia

If a person have Thalassemia mibor, te cause of the slight anemia is known or no other blood tests or treatment suc as iron are needed more important, since individual wit Thalassemia minor can pass the Thalassemia minor the Thalassemia gene to their childern, most people would like to know there is a inherit risk that their childern could where it this sever blood disease a safa and reliable parental test to diagnose Thalassemia major in a early as 10-12 weeks after conception has been developed couple who are at risk may want to consider this possiblity.

 

Research is being carriec out focusing on :- finding ways to increase hemoglobin production in red blood cells finding new medicines to remove iron, especially ones that can taken orally. Transplantation of normal bone marrow or stem cells gives therapy relapse thalassemia gene and normal gene.